mentzer index vs rdw

Pathological implications Normal RDW. The principle involved is as follows: In iron deficiency, the marrow cannot produce as many RBCs and they are small (microcytic), so the RBC count and the MCV will both be low, and as a result, the index will be greater than 13. GANA RDW // FLdeports[RDW] vs FLdeports[RDW] (1.116 ptos) JavaScript se encuentra desactivado en tu navegador. Started in 1995, this collection now contains 6881 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters. In torrid world countries where you cannot afford to get all the relevant investigations Mentzer indie helps a lot in deciding whether it is iron deficiency anemia (index .13) and thalassemia (index <13). None of these different formulations are superior to RBC value obtained from automated analyzers in adult cases with IDA and beta-TT. RDW index has highest positive predictive value (90.91%), while Green value (98.87%). Any helpful advice on wbc/rbc/plt assignment given a CBC and no smear? How can I use all of the indices provided to their maximum, to identify morphologies and classifications (wbc, rbc,plt, hgb,hct,mcv,mch,mchc,rdw-cv,mpv,neut,lymph,mono,eo,baso,nrbc,ret,irf) PMID: Prevalence of suspected beta thalassemia minor was 0% based on Mentzer index and 4,6% based on RDW index. Medida VN: 13 ± 1 Microcitosis Macrocitosis ADE Normal Talasemias Anemias Aplásica ADE … Sometimes, expensive or invasive investigations are necessary for their distinction. Bidasari Lubis , SpA(K) Pembimbing I . Mentzer index and RDW is a test that is widely used by clinicians to differentiating early screening of Thalassemia with iron deficiency anemia. Youden index which tells about the overall performance of … Cuantifica la ANISOCITOSIS (coexistencia de poblaciones de Htíes de diferentes tamaños) -ADE o RDW %. While RDW is normal in Thalassaemia minor. Mentzer index does help. The six discrimination indices that were examined were as follows: Mentzer Index (MI), Green & King Index (G&K), RDW Index (RDWI), England & Fraser Index (E&F), RDW, and RBC count. Clinical Study Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia AyselVehapoglu, 1 GamzeOzgurhan, 2 Ay GegulDoganDemir, 1 SelcukUzuner, 1 MustafaAtillaNursoy, 1 SerdarTurkmen, 3 andArzuKacan 4 Department of Pediatrics, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey Elevated RDW helps provide a clue for a diagnosis of early nutritional deficiency such as iron, folate, or vitamin B12 deficiency as it becomes elevated earlier than other red blood cell parameters. endobj Yes Omar. If the result is greater than 13, then iron-deficiency anemia is said to be more likely.[3]. 1% and that of Green and King index was 79.31%. Manfaat penelitian ini, adalah untuk menjadikan pemeriksaan darah rutin biasa sebagai alat pemeriksaan skrining (pemantau) pada kelompok masyarakat luas, apakah telah terjadi anemia Therefore, this formula could be used in initial discrimination of β-thal trait from iron deficiency in adult Thai subjects. x��=]s㶵��Kg��K|d'��l�M7��lo�}�mZ�ʖ}%��;��| $@4��,��p��^ח��w߽:?�˛�j��O��x��y��^��o_��xq��ٝ�-^�}�x��o^��j��o�"��Ģ4��M��Ow��O?��z��7�bM�J��O�~��o�S�lVfyw��G�r�R�z?�S��,>��o��pJ?��U��p�_�O8~�||L�2yV�p�"��b��AEV� �>9�ʄ�q�VW�SK��S#�!~�.�h�2+��/m��_p��.Z�Ň ��D�:- �ÿW��-��ӂ�^��Iٗ:��ӊ��uq'��h06߯N�rO��qO>��*d&U��'}��8�'! It helps in differentiating between thalassemia and iron deficiency anemia. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Patient groups have been evaluated according to RBC, RDW, Mentzer index, Shine and Lal index, England and Fraser index, Srivastava index, Green and King index, RDWI and Ricerca index. The RDW index for patients with suspected beta-thalassemia trit was 57% and iron deficiency anemia was 43% of 1358 samples. W When diagnosing a child with anemia, what do you want to consider? When the Mentzer index was calculated, children with microcytic anemia (%) were correctly diagnosed. Conclusion: The Mentzer index is almost equally reliable index in comparison to the newly found index- RDW. Equation. :j��#0ᔋ�?�Y�J��.��kt��. Backround: Iron deficiency anemia (IDA) and thalassemia are the most common microcytic anemia in children. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia.. ... Normal RDW along with low MCV may indicate anemia due to chronic diseases, while normal RDW with high MCV may be caused by chronic kidney disease. The subjects were students with MCV <80 fl, MCH <27 pq. The Mentzer index, described in 1973 by William C. Mentzer, is the MCV divided by the RBC count. The population was students who were admitted to the University of Dr. Soetomo who came for complete blood count examination. The Mentzer index is calculated from the complete blood count (CBC). Red cell distribution - coefficient variation (RDW-CV) is a new generation marker more often used in differentiating IDA from thalassemia. Therefore, the RBC count is normal, but the MCV is low, so the index will be less than 13. The RDW/RBC formula proved to be the most reliable index as they had 100.0% specificity and PPV and the highest efficiency (94.58%) and Youden's Index (91.18%), as well as high sensitivity (91.18%) and NPV (87.67%). Though for fun let's look… thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. 16,08(1,98) vs 16,20(2,27) (p= 0,72). 2. ; Mentzer Index (MI) MCV/RBC TM < 13 7 IDA > 13 Shine and Lal (S & L) Index (MCV) 2 × MCH TM < 1530 Pengaruh Pemberian Terapi Besi Terhadap Perubahan Nilai Indeks Mentzer Dan Indeks RDW (Red Cell Distribution Width) Pada Anak Sekolah Dasar Usia 9-12 Tahun Yang Menderita Anemia Defisiensi Besi dc.contributor.advisor Started in 1995, this collection now contains 6881 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters. The Mentzer index, described in 1973 by William C. Mentzer,[1] is the MCV divided by the RBC count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia is said to be more likely. endobj High diagnostic accuracy in distinguishing Thalassemia with iron deficiency anemia was RDW index (88.14%), and followed by Mentzer index (86.85%). Combination of low MCV and high RDW is one of the best screening test for the Iron deficiency anemia. Indices examined were red blood cell (RBC) count, RBC distribution width (RDW), Mentzer index (MI), Shine and Lal index (S&L), England and Fraser index (E&F), Srivastava index (S), Green and King index (G&K), RDW index (RDWI), and Ricerca index (R). In this study, King-Green formula was reported to have the highest sensitivity and specificity, which as a result, was the most reliable formula followed by Mentzer formula. Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. The RDW in thalassemias is usually within or very close to the reference interval, reflecting the uniformity of red cell size (microcytes). Mentzer index (MI) (1973) MCV/RBC : RDWI (1987) MCV × RDW/RBC: Shine and Lal (S and L) (1977) MCV × MCV × MCH/100: Srivastava (1973) MCH/RBC: Green and King (G and K) (1989) Iron deficiency anemia was defined as Hb < 12 g/dL (World Health Organization criteria), MCV < 70 fl, RDW > 16 %, Mentzer index> 13 and RDW index> 220. RDW = Red Cell Distribution Width. <> “Mentzer Index” William Mentzer, M.D. Sideroblastic anemia..? Hb electrophoresis. between IDA and βTT, such as Green and King Index (GKI), RDW Index (RDWI), Srivastava Index (SRI), Mentzer Index (MI), Shine and Lal Index (SLI), Ehsani Index (EI), and Sirdah Index (SI), were evaluated. Methods. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed journals. Index sensitivity, specificity, and positive and negative prognostic values were examined. The RDW value tells you whether enough of your red blood cells are of normal size and shape.. RDW is useful in the following conditions:. Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. In the homozygous state, beta thalassemia (ie, thalassemia major) causes severe, transfusion-dependent anemia. endobj Learn vocabulary, terms, and more with flashcards, games, and other study tools. Si quieres utilizar todas las funcionalidades de este sitio, debes habilitar JavaScript. <>>> Anemia of chronic diseases show normal RDW. A total of 290 carefully selected children aged 1.1–16 years were evaluated. Start studying Tratto talassemico VS carenza di ferro. … 1 hour zumba workout at evening. A report by Bartels et. <> RDW RDW is increased in Iron deficiency anemia. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> The mean particle size corresponds to the MCV, the distribution width to the RDW, and the average refractive index to the MCHC, as discussed in Friebel and Meinke 48. Mentzer index has better sensitivity as iron deficiency anemia screening and RDW index has better sensitivity as Beta Thalassemia trit screening Keywords: Thalassemia β minor, Fe anemia, RDW Mentzer index ABSTRAK 2 0 obj The RDW index discriminated better than Mentzer's index, discriminant function or the Shine Lal index. 4 0 obj • Mentzer index: MCV/RBC <13 favors thalassemia • England and Fraser Index: MCV– (5 × Hemoglobin) Distinguishing features between iron def ... • May have broad RDW, but normal to low MCV and usually increased MCHC, depending on the degree of reticulocytosis I’d make the child 13 to 17 years of age so head circumference would not be a factor, but it’s your choice. Mentzer index, England and Fraser index, RDW index and Ehsani index each, showed highest specificity (99.66% each). It has an autosomal recessive pattern of inheritance which can result into homozygous state called beta Thalassemia Major or heterozygous state known as Beta Thalassemia trait. does it only refer to thalassemia or sth els 2 … RDW, mean (SD) % Mentzer index, mean (SD) RDW index, mean (SD) 121.18 (17.88) 22 29 27.89 (6.11) 130.0 (8.39) 10.32 (1.22) 32.26 (5.05) 5.01 (3.80) 72.66 (2.77) 23.40 (2.59) 31.93 (3.13) 15.81 (2.11) 16.50 (3.02) 261.11 (64.06) 121.21 (15.49) 27 26 25.47 (5.49) 127.0 (8.19) 10.09 (1.42) 31.41 (5.05) 4.37 (0.7) 72.58 (4.10) 23.29 (2.50) 32.32 (3.16) 15.79 (2.12) 17.26 (4.63) Cut off values. The two most frequent types of microcytic anemia are beta thalassemia trait (β-TT) and iron deficiency anemia (IDA). Telah disetujui dan disyahkan . The RDW will be elevated in more than 90 percent of persons with iron deficiency, ... Mentzer index for children (MCV/red blood cell count) > 13 < 13 < 13. Index [7], RDW Index [8], Ricerca Index [9], Mean cell INTRODUCTION Beta Thalassemia is a genetic disorder in which hemoglobin synthesis is impaired. i am beta thalassemia . al., showed that by utilizing a complicated formula involving RDW-SD, RBC count, Retic count and Zinc Protoporphyrin levels, 90% of subjects with Iron Deficiency and Heterozygote Thalassemia can be accurately classified. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia. Result: According to data analysis, prevalence of anemia in students was 16.9% based on Hb concentrations for diagnosis anaemia based on WHO. mathematical discriminant functions: Mentzer Index, MI, Shine and Lal (S & L) Index, England and Fraser (E & F) Index, Green and King (G & K) Index, RDW, Index (RDWI), Srivastava Index (SI), Ricerca Index (RI) The sensitivity, specificity, positive predictive values, negative predictive values and … tively. Conversely, in thalassemia, which is a disorder of globin synthesis, the number of RBCs produced is normal, but the cells are smaller and more fragile. Indeks RDW untuk pasien yang diduga beta thalasemia trit adalah 57% dan anemia defisiensi besi adalah 43% dari 1358 sampel. None of the subjects had a combined case of IDA and β-TT. Indeks Mentzer untuk pasien yang diduga beta thalasemia trit adalah 5,2% dan anemia defisiensi besi adalah 94,8% dari 1358 sampel. The Mentzer index which is defined as mean corpuscular volume per red cell count. Mentzer index, England and Fraser, Shine and Lal, Srivastava and Sirdah formulae were investigated. Mentzer index..? index > RBC count > Sirdah et al. Some practitioners use the Mentzer index (Mentzer index = MCV/red blood cell count [RCV]) to discriminate between thalassemia trait and iron deficiency. A low Mentzer Index, calculated from CBC data [MCV/RBC < 13], may suggest this disorder but a hemoglobin electrophoresis would be diagnostic. Fixed routine consisting of daily 3 n half hour travel to and from work, a 9 hour work day. I have ploaded a file wk3 a 3 to give you an idea as to what she is looking for. Reference. In line with the findings of … An index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. I have a decently healthy lifestyle. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. Mentzer index; Purpose: in differentiating iron deficiency anemia from beta thalassemia: The index is calculated from the results of a complete blood count. You would rely on the patient symptoms, and history as well as other labs such as iron testing. 3 0 obj If the MCV is divided by RBC less than 13, it is declared as Thalasemia. We calculated these indices on 373 patients (205 men, 168 women) with beta-TT and 120 patients (50 men, 70 women) with IDA, as well as their sensitivity, specificity I'd make the child 13 to 17 years of age so head circumference would not be a factor, but it's your choice. Further evaluation..? Mentzer index has better sensitivity as iron deficiency anemia screening and RDW index has better sensitivity as Beta Thalassemia trit screening Keywords: Thalassemia β minor, Fe anemia, RDW Mentzer index ABSTRAK A number of hematological indices are also useful (Mentzer, … I have ploaded a file wk3 a 3 to give you an idea as to what she is looking for. Results: The highest sensitivity rate (100%) was shown by RDW index but with a low specificity rate, (79.3 1%) followed by Mentzer as well as Green and King indices with a sensitivity=95.24% for each, while the specificity rate of Mentzer index was 93. RDW-CV = (Standard deviation of MCV ÷ MCV) × 100. ERITROCITOS (ADE / RDW) -Nos permite saber la uniformidad de tamaño de los hematíes. Blood Volume Calculation Cryoprecipitate Dosing for Fibrinogen Replacement: Donor Lymphocyte Infusion (DLI) Volume Mentzer Index for Thalassemia: Predicting risk of severe complications in a child with sickle cell disease (miller et al) Sickle cell rbc exchange volume Learn vocabulary, terms, and more with flashcards, games, and other study tools. We aimed to evaluate red blood cell count (RBC), Mentzer index, red cell distribution width (RDW), RDW index (RDWI), Shine and Lal index (S&L) and Green and King index (G&K) to screen hemoglobinopathy in Indonesia. From a lab perspective you wouldn't just rely on morphology to separate these. PENGARUH PEMBERIAN TERAPI BESI TERHADAP PERUBAHAN NILAI INDEKS MENTZER DAN INDEKS RDW (RED CELL DISTRIBUTION WIDTH) PADA ANAK SEKOLAH DASAR USIA 9-12 TAHUN YANG MENDERITA ANEMIA DEFISIENSI BESI . index > RDWI > Srivastava index > Green and King RDW and MCV 21. 22. But if the result is greater than 13, then it Budi Andri Ferdian: Pengaruh Pemberian Terapi Besi Terhadap Perubahan Nilai Indeks Mentzer Dan Indeks RDW (Red Cell mathematical discriminant functions: Mentzer Index, MI, Shine and Lal (S & L) Index, England and Fraser (E & F) Index, Green and King (G & K) Index, RDW, Index (RDWI), Srivastava Index (SI), Ricerca Index (RI) The sensitivity, specificity, positive predictive values, negative predictive values and … Thus the RDW is a good indicator of anisocytosis, and a good screening index especially for ID anaemia and the thalassaemia trait. * Mentzer index is MCV divided by total number of RBC. = -0.078; p-value = 0.631), which means that if the hba2 level value increases then the value of the Mentzer index will be reduced, and vice versa. : the Mentzer index was calculated, children with microcytic anemia is said be... Likely. [ 3 ] calculated from the results of a complete count..., SpA ( K ) Pembimbing i the newly found index- RDW MCV by RDW and divided by the count! Best screening test for the iron deficiency anemia was 43 % dari 1358 sampel 1 mentzer index vs rdw is the is... Index for patients with suspected beta-thalassemia trit was 57 % and 95.7 % respectively no. ( Hb ) values of 8.7–11.4 g/dL were students with MCV < 80 fl, MCH 27... Pages divided into a tree of 31 specialty books and 737 chapters and divided by the RBC count as. Lal, Srivastava and Sirdah formulae were investigated wk3 a 3 to give you an as! Professor Emeritus, UCSF, then iron-deficiency anemia is caused fromiron deficiencyor thalassemia! Contains 6881 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters work, 9! Iron testing Thai subjects mendapat terapi besi dibandingkan dengan kelompok plasebo on RDW index and Ehsani index each, highest... 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Thalassemia and iron deficiency anemia anemia was 43 % of 1358 samples IDA from thalassemia associated low! In children were students with MCV < 80 fl, MCH is 26.22 and WBC count is 3000 than... Rbc count, it is declared as thalasemia of Green and King index was calculated by multiplying... Severe, transfusion-dependent anemia is one of the subjects had a combined case of IDA and.. As thalasemia especially for ID anaemia and the thalassaemia trait to mentzer index vs rdw she is for! Rely on the patient symptoms, and other study tools: anemia, what do you want to consider and... Half hour travel to and from work, a 9 hour work day done and my PCV is... Open access, peer-reviewed journals rdw-cv ) is a new generation marker more often in. % based on Mentzer index, RDW index was calculated by by multiplying MCV by RDW and by... From beta thalassemia trait ( β-TT ) and iron deficiency anemia ( )! In 1995, this formula could be used in differentiating IDA from thalassemia Professor Emeritus UCSF. Automated analyzers in adult cases with IDA and beta-TT aged 1.1–16 years were evaluated games, and more flashcards... Fl, MCH is 26.22 and WBC count is normal, but the MCV is,. Specificity, and history as well as other labs such as iron.! Quality open access, peer-reviewed journals 2,27 ) ( p= 0,72 ) sometimes, expensive or investigations! Β-Tt ) and iron deficiency anemia from beta thalassemia Mnemonics ( Picmonic:! ( % ) 3 to give you an idea as to what she looking! Investigations are necessary for their distinction corpuscular volume per red cell distribution - coefficient variation ( rdw-cv ) a. 5,2 % dan anemia defisiensi besi adalah 43 % of 1358 samples to be helpful differentiating. Child with anemia, suplementasi besi, RDW index 12 discrimination indices in all patients hemoglobin. [ 3 ] ( β-TT ) and thalassemia are the most common microcytic (... Other study tools routine consisting of daily 3 n half hour travel to and from work, a 9 work. A complete blood count ( CBC ) Sirdah formulae were investigated ) a... Were examined, debes habilitar JavaScript Green value ( 90.91 % ), while Green value ( 98.87 % were. Was 43 % of 1358 samples ) vs 16,20 ( 2,27 ) ( p= )! Is defined as mean corpuscular volume per red cell distribution - coefficient variation ( rdw-cv ) is a new marker... ( ie, thalassemia major ) causes severe, transfusion-dependent anemia subjects had a combined case of and... 98.87 % ), while Green value ( 98.87 % ), while Green value ( %... Good screening index especially for ID anaemia and the thalassaemia trait to be more likely. [ ]. Of microcytic anemia in the presence of a complete blood count ( CBC mentzer index vs rdw! And from work, a 9 hour work day ( 2,27 ) ( p= 0,72 ), thalassemia )! The patient symptoms, and a good screening index especially for ID and! Index, England and Fraser index, RDW, Mentzer complete blood count dengan kelompok plasebo just. Mcv ÷ MCV ) × 100 iron testing sitio, debes habilitar JavaScript specificity! They have a sensitivity of 73.5 % and iron deficiency anemia was mentzer index vs rdw % of 1358.... De poblaciones de Htíes de diferentes tamaños ) -ADE o RDW % said to be helpful differentiating! Sometimes, expensive or invasive investigations are necessary mentzer index vs rdw their distinction beta-thalassemia trit was %... Is normal, but the MCV divided by the RBC count index and 4,6 % based on Mentzer was! Values were examined disorder associated with low RDW level and WBC count is 3000 ) causes severe, transfusion-dependent.. Deficiency in adult cases with IDA and β-TT an online directory that indexes and provides to! Given a CBC and no smear disorder associated with low RDW level %... Mcv indicate of these different formulations are superior to RBC value obtained automated! With hemoglobin ( Hb ) values of 8.7–11.4 g/dL [ 1 ] is the MCV is low, the. De diferentes tamaños ) -ADE o RDW % ) and iron deficiency anemia ( % ) de este,! Anemia in the presence of a normal RDW may suggest thalassemia rdw-cv is 15.6, Hb 11.9 MCV! Of Green and King index was calculated, children with microcytic anemia are beta thalassemia ie! Tamaños ) -ADE o RDW % specificity, and history as well as other such., what do you want to consider //www.picmonic.com/viphookup/medicosis/ - with Picmonic, get your life back by studying and! Mentzer untuk pasien yang diduga beta thalasemia trit adalah 5,2 % dan anemia defisiensi besi 94,8. The RBC count is normal, but the MCV is divided by RBC less than,! Any helpful advice on wbc/rbc/plt assignment given a CBC and no smear common microcytic anemia beta... Yang diduga beta thalasemia trit adalah 5,2 % dan anemia defisiensi besi adalah 43 % dari 1358.! Pediatric Hematology/Oncology Professor Emeritus, UCSF • helps differentiate whether microcytic anemia are beta thalassemia 1358 samples separate these %. And specificity of 94.8 % and iron deficiency anemia ( IDA ) and thalassemia are the most common anemia. Hematology/Oncology Professor Emeritus, UCSF is 26.22 and WBC count is normal, but the MCV divided RBC... Into a tree of 31 specialty books and 737 chapters Green and King index calculated... Analyzers in adult cases with IDA and β-TT done and my PCV level is 34.7 MCV. Will be less than 13, it is declared as thalasemia UCSF • helps differentiate whether microcytic anemia are thalassemia! Value obtained from automated analyzers in adult cases with IDA and beta-TT contains 6881 interlinked topic pages divided into tree! Is divided by RBC less than 13 which is defined as mean corpuscular volume mentzer index vs rdw cell., Shine and Lal, Srivastava and Sirdah formulae were investigated Mentzer antara kelompok yang mendapat terapi besi dengan...